AffectedAnimals:
Dogs.

Overview:
A developmental bone disease usually affecting puppies between the ages of two and eight months, hypertrophic osteodystrophy, or HOD, occurs when there is a disturbance in the blood supply to the growth plate, leading to delays in bone production. This weakened bony lattice develops microscopic fractures, with the resulting inflammation causing pain and lameness. When HOD is severe, the dog may become systemically ill; loss of appetite, depression, and dehydration are common symptoms.

1. Fibula
2. Tibia
3. Distal Tibia with Enlarged Metaphysis
4. Calcaneus

The breeds most frequently affected by HOD include the Great Dane, Irish wolfhound, Saint Bernard, Doberman pinscher, German shepherd, and the weimaraner.