The treatment of parvovirus is supportive care because there is no cure. Fluid therapy, usually given intravenously at a veterinary hospital, is critical in preventing dehydration and replacing fluids lost through vomiting and diarrhea. Animals typically are hospitalized and kept on fluid therapy for several days, until they are able to hold down water and food. Food and drink should not be given for 24 to 72 hours to allow the intestines time to recover. Fluids given under the skin can be beneficial as well, but there is a risk of tissue damage and cell death, or necrosis and infection through repeated skin injections.
A veterinarian usually will give the dog antibiotics to prevent infection due to bacteria. Antiemetic medications, beneficial in preventing nausea and vomiting, may be given as well. Antacids can be given to prevent damage to the esophagus from vomiting acidic fluids. With quick, aggressive medical therapy, the majority of animals survive.