Antifungal drugs including ketoconazole, itraconazole, fluconazole, and amphotericin B are the mainstay of treatment. Amphotericin B was one of the first drugs found to be effective in the treatment of blastomycosis. It can cause kidney damage, and requires intravenous administration.
Ketoconazole, itraconazole, and fluconazole belong to the same drug family. Each has been used effectively in the treatment of Blastomycosis. Ketoconazole and itraconazole can cause liver damage, and are available as oral medications. Itraconazole is generally more effective than ketoconazole, but it is also more expensive. Fluconazole is often used for treating infections of the central nervous system and eye because of its better penetration into these tissues.
